Publikationen

2022

Herpes simplex viorus alters Alzheimer´s disease biomarkers - A hypothesis paper(link is external)

Goldhardt O, Freiberger R, Dreyer T, Wilner L, Yakushev I, Ortner M, Förrst H, Diehl-Schmid J, Milz E,  Priller J, Ramirez A, Magdolen V, Thaler M, Grimmer T.                        Alheimers Dement. 2022 Nov 17 doi: 10.1002/alz.12834.   

Cognitive impairment and microvascular function in end-stage renal disease. (link is external)

Angermann S, Günthner R, Hanssen H, Lorenz G, Braunisch MC, Steubl D, Matschkal J, Kemmner S, Hausinger R, Block Z, Haller B, Heemann U, Kotliar K, Grimmer T, Schmaderer C. Int J Methods Psychiatr Res. 2022 Mar 15:e1909. doi: 10.1002/mpr.1909. Online ahead of print. PMID: 35290686

Mapping covariance in brain FDG uptake to structural connectivity. (link is external)

Yakushev I, Ripp I, Wang M, Savio A, Schutte M, Lizarraga A, Bogdanovic B, Diehl-Schmid J, Hedderich DM, Grimmer T, Shi K. Eur J Nucl Med Mol Imaging. 2022 Mar;49(4):1288-1297. doi: 10.1007/s00259-021-05590-y. Epub 2021 Oct 22. PMID: 34677627 Free PMC article.​​​​​​​

Prevalence Estimates of Amyloid Abnormality Across the Alzheimer Disease Clinical Spectrum. (link is external)

Jansen WJ, Janssen O, Tijms BM, Vos SJB, Ossenkoppele R, Visser PJ; Amyloid Biomarker Study Group, Aarsland D, Alcolea D, Altomare D, von Arnim C, Baiardi S, Baldeiras I, Barthel H, Bateman RJ, Van Berckel B, Binette AP, Blennow K, Boada M, Boecker H, Bottlaender M, den Braber A, Brooks DJ, Van Buchem MA, Camus V, Carill JM, Cerman J, Chen K, Chételat G, Chipi E, Cohen AD, Daniels A, Delarue M, Didic M, Drzezga A, Dubois B, Eckerström M, Ekblad LL, Engelborghs S, Epelbaum S, Fagan AM, Fan Y, Fladby T, Fleisher AS, Van der Flier WM, Förster S, Fortea J, Frederiksen KS, Freund-Levi Y, Frings L, Frisoni GB, Fröhlich L, Gabryelewicz T, Gertz HJ, Gill KD, Gkatzima O, Gómez-Tortosa E, Grimmer T, Guedj E, Habeck CG, Hampel H, Handels R, Hansson O, Hausner L, Hellwig S, Heneka MT, Herukka SK, Hildebrandt H, Hodges J, Hort J, Huang CC, Iriondo AJ, Itoh Y, Ivanoiu A, Jagust WJ, Jessen F, Johannsen P, Johnson KA, Kandimalla R, Kapaki EN, Kern S, Kilander L, Klimkowicz-Mrowiec A, Klunk WE, Koglin N, Kornhuber J, Kramberger MG, Kuo HC, Van Laere K, Landau SM, Landeau B, Lee DY, de Leon M, Leyton CE, Lin KJ, Lleó A, Löwenmark M, Madsen K, Maier W, Marcusson J, Marquié M, Martinez-Lage P, Maserejian N, Mattsson N, de Mendonça A, Meyer PT, Miller BL, Minatani S, Mintun MA, Mok VCT, Molinuevo JL, Morbelli SD, Morris JC, Mroczko B, Na DL, Newberg A, Nobili F, Nordberg A, Olde Rikkert MGM, de Oliveira CR, Olivieri P, Orellana A, Paraskevas G, Parchi P, Pardini M, Parnetti L, Peters O, Poirier J, Popp J, Prabhakar S, Rabinovici GD, Ramakers IH, Rami L, Reiman EM, Rinne JO, Rodrigue KM, Rodríguez-Rodriguez E, Roe CM, Rosa-Neto P, Rosen HJ, Rot U, Rowe CC, Rüther E, Ruiz A, Sabri O, Sakhardande J, Sánchez-Juan P, Sando SB, Santana I, Sarazin M, Scheltens P, Schröder J, Selnes P, Seo SW, Silva D, Skoog I, Snyder PJ, Soininen H, Sollberger M, Sperling RA, Spiru L, Stern Y, Stomrud E, Takeda A, Teichmann M, Teunissen CE, Thompson LI, Tomassen J, Tsolaki M, Vandenberghe R, Verbeek MM, Verhey FRJ, Villemagne V, Villeneuve S, Vogelgsang J, Waldemar G, Wallin A, Wallin ÅK, Wiltfang J, Wolk DA, Yen TC, Zboch M, Zetterberg H. JAMA Neurol. 2022 Mar 1;79(3):228-243. doi: 10.1001/jamaneurol.2021.5216. PMID: 35099509

Decoupling of regional neural activity and inter-regional functional connectivity in Alzheimer's disease: a simultaneous PET/MR study. (link is external)

Maleki Balajoo S, Rahmani F, Khosrowabadi R, Meng C, Eickhoff SB, Grimmer T, Zarei M, Drzezga A, Sorg C, Tahmasian M. Eur J Nucl Med Mol Imaging. 2022 Feb 24. doi: 10.1007/s00259-022-05692-1. Online ahead of print. PMID: 35199225​​​​​​​

2021

Neuronavigated repetitive transcranial magnetic stimulation as novel mapping technique provides insights into language function in primary progressive aphasia. (link is external)

Mueller-Sarnowski F, Sollmann N, Schröder A, Houri L, Ille S, Grimmer T, Krieg SM, Diehl-Schmid J. Brain Imaging Behav. 2021 Dec 28. doi: 10.1007/s11682-021-00605-6.    Online ahead of print. PMID: 34964088​​​​​​​

Common variants in Alzheimer's disease and risk stratification by polygenic risk scores. (link is external)

de Rojas I, Moreno-Grau S, Tesi N, Grenier-Boley B, Andrade V, Jansen IE, Pedersen NL, Stringa N, Zettergren A, Hernández I, Montrreal L, Antúnez C, Antonell A, Tankard RM, Bis JC, Sims R, Bellenguez C, Quintela I, González-Perez A, Calero M, Franco-Macías E, Macías J, Blesa R, Cervera-Carles L, Menéndez-González M, Frank-García A, Royo JL, Moreno F, Huerto Vilas R, Baquero M, Diez-Fairen M, Lage C, García-Madrona S, García-González P, Alarcón-Martín E, Valero S, Sotolongo-Grau O, Ullgren A, Naj AC, Lemstra AW, Benaque A, Pérez-Cordón A, Benussi A, Rábano A, Padovani A, Squassina A, de Mendonça A, Arias Pastor A, Kok AAL, Meggy A, Pastor AB, Espinosa A, Corma-Gómez A, Martín Montes A, Sanabria Á, DeStefano AL, Schneider A, Haapasalo A, Kinhult Ståhlbom A, Tybjærg-Hansen A, Hartmann AM, Spottke A, Corbatón-Anchuelo A, Rongve A, Borroni B, Arosio B, Nacmias B, Nordestgaard BG, Kunkle BW, Charbonnier C, Abdelnour C, Masullo C, Martínez Rodríguez C, Muñoz-Fernandez C, Dufouil C, Graff C, Ferreira CB, Chillotti C, Reynolds CA, Fenoglio C, Van Broeckhoven C, Clark C, Pisanu C, Satizabal CL, Holmes C, Buiza-Rueda D, Aarsland D, Rujescu D, Alcolea D, Galimberti D, Wallon D, Seripa D, Grünblatt E, Dardiotis E, Düzel E, Scarpini E, Conti E, Rubino E, Gelpi E, Rodriguez-Rodriguez E, Duron E, Boerwinkle E, Ferri E, Tagliavini F, Küçükali F, Pasquier F, Sanchez-Garcia F, Mangialasche F, Jessen F, Nicolas G, Selbæk G, Ortega G, Chêne G, Hadjigeorgiou G, Rossi G, Spalletta G, Giaccone G, Grande G, Binetti G, Papenberg G, Hampel H, Bailly H, Zetterberg H, Soininen H, Karlsson IK, Alvarez I, Appollonio I, Giegling I, Skoog I, Saltvedt I, Rainero I, Rosas Allende I, Hort J, Diehl-Schmid J, Van Dongen J, Vidal JS, Lehtisalo J, Wiltfang J, Thomassen JQ, Kornhuber J, Haines JL, Vogelgsang J, Pineda JA, Fortea J, Popp J, Deckert J, Buerger K, Morgan K, Fließbach K, Sleegers K, Molina-Porcel L, Kilander L, Weinhold L, Farrer LA, Wang LS, Kleineidam L, Farotti L, Parnetti L, Tremolizzo L, Hausner L, Benussi L, Froelich L, Ikram MA, Deniz-Naranjo MC, Tsolaki M, Rosende-Roca M, Löwenmark M, Hulsman M, Spallazzi M, Pericak-Vance MA, Esiri M, Bernal Sánchez-Arjona M, Dalmasso MC, Martínez-Larrad MT, Arcaro M, Nöthen MM, Fernández-Fuertes M, Dichgans M, Ingelsson M, Herrmann MJ, Scherer M, Vyhnalek M, Kosmidis MH, Yannakoulia M, Schmid M, Ewers M, Heneka MT, Wagner M, Scamosci M, Kivipelto M, Hiltunen M, Zulaica M, Alegret M, Fornage M, Roberto N, van Schoor NM, Seidu NM, Banaj N, Armstrong NJ, Scarmeas N, Scherbaum N, Goldhardt O, Hanon O, Peters O, Skrobot OA, Quenez O, Lerch O, Bossù P, Caffarra P, Dionigi Rossi P, Sakka P, Hoffmann P, Holmans PA, Fischer P, Riederer P, Yang Q, Marshall R, Kalaria RN, Mayeux R, Vandenberghe R, Cecchetti R, Ghidoni R, Frikke-Schmidt R, Sorbi S, Hägg S, Engelborghs S, Helisalmi S, Botne Sando S, Kern S, Archetti S, Boschi S, Fostinelli S, Gil S, Mendoza S, Mead S, Ciccone S, Djurovic S, Heilmann-Heimbach S, Riedel-Heller S, Kuulasmaa T, Del Ser T, Lebouvier T, Polak T, Ngandu T, Grimmer T, Bessi V, Escott-Price V, Giedraitis V, Deramecourt V, Maier W, Jian X, Pijnenburg YAL; EADB contributors; GR@ACE study group; DEGESCO consortium; IGAP (ADGC, CHARGE, EADI, GERAD); PGC-ALZ consortia, Kehoe PG, Garcia-Ribas G, Sánchez-Juan P, Pastor P, Pérez-Tur J, Piñol-Ripoll G, Lopez de Munain A, García-Alberca JM, Bullido MJ, Álvarez V, Lleó A, Real LM, Mir P, Medina M, Scheltens P, Holstege H, Marquié M, Sáez ME, Carracedo Á, Amouyel P, Schellenberg GD, Williams J, Seshadri S, van Duijn CM, Mather KA, Sánchez-Valle R, Serrano-Ríos M, Orellana A, Tárraga L, Blennow K, Huisman M, Andreassen OA, Posthuma D, Clarimón J, Boada M, van der Flier WM, Ramirez A, Lambert JC, van der Lee SJ, Ruiz A. Nat Commun. 2021 Jun 7;12(1):3417. doi: 10.1038/s41467-021-22491-8. PMID: 34099642 Free PMC article.

Intepirdine as adjunctive therapy to donepezil for mild-to-moderate Alzheimer's disease: A randomized, placebo-controlled, phase 3 clinical trial (MINDSET). (link is external)

Lang FM, Mo Y, Sabbagh M, Solomon P, Boada M, Jones RW, Frisoni GB, Grimmer T, Dubois B, Harnett M, Friedhoff SR, Coslett S, Cummings JL. Alzheimers Dement (N Y). 2021 May 31;7(1):e12136. doi: 10.1002/trc2.12136. eCollection 2021. PMID: 34095437 Free PMC article.

Age-Dependency of Total Tau in the Cerebrospinal Fluid Is Corrected by Amyloid-β 1-40: A Correlational Study in Healthy Adults. (link is external)

Zebhauser PT, Berthele A, Franz MS, Goldhardt O, Diehl-Schmid J, Priller J, Ortner M, Grimmer T. J Alzheimers Dis. 2021;83(1):155-162. doi: 10.3233/JAD-210286. PMID: 34250938

2020

European Academy of Neurology/European Alzheimer's Disease Consortium position statement on diagnostic disclosure, biomarker counseling, and management of patients with mild cognitive impairment. (link is external)

Frederiksen KS, Nielsen TR, Winblad B, Schmidt R, Kramberger MG, Jones RW, Hort J, Grimmer T, Georges J, Frölich L, Engelborghs S, Dubois B, Waldemar G. Eur J Neurol. 2021 Jul;28(7):2147-2155. doi: 10.1111/ene.14668. Epub 2020 Dec 23. PMID: 33368924 Free PMC article.

Biomarker counseling, disclosure of diagnosis and follow-up in patients with mild cognitive impairment: A European Alzheimer's disease consortium survey. (link is external)

Frederiksen KS, Nielsen TR, Appollonio I, Andersen BB, Riverol M, Boada M, Ceccaldi M, Dubois B, Engelborghs S, Frölich L, Hausner L, Gabelle A, Gabryelewicz T, Grimmer T, Hanseeuw B, Hort J, Hugon J, Jelic V, Koivisto A, Kramberger MG, Lebouvier T, Lleó A, de Mendonça A, Nobili F, Ousset PJ, Perneczky R, Olde Rikkert M, Robinson D, Rouaud O, Sánchez E, Santana I, Scarmeas N, Sheardova K, Sloan S, Spiru L, Stefanova E, Traykov L, Yener G, Waldemar G. Int J Geriatr Psychiatry. 2021 Feb;36(2):324-333. doi: 10.1002/gps.5427. Epub 2020 Sep 16. PMID: 32896040

Biomarker Testing: Piercing the Fog of Alzheimer's and Related Dementia. (link is external)

Horgan D, Nobili F, Teunissen C, Grimmer T, Mitrecic D, Ris L, Pirtosek Z, Bernini C, Federico A, Blackburn D, Logroscino G, Scarmeas N. Biomed Hub. 2020 Nov 23;5(3):19-40. doi: 10.1159/000511233. eCollection 2020 Sep-Dec. PMID: 33564663 Free PMC article.

Value of a Panel of 6 Serum Biomarkers to Differentiate Between Healthy Controls and Mild Cognitive Impairment Due to Alzheimer Disease. (link is external)

Schipke CG, Menne F, Rubow S, Sigle JP, Peters O, Grimmer T. Alzheimer Dis Assoc Disord. 2020 Oct-Dec;34(4):318-324. doi: 10.1097/WAD.0000000000000397. PMID: 32649324

Correction:18F-FIBT may expand PET for β-amyloid imaging in neurodegenerative diseases. (link is external)

Grimmer T, Shi K, Diehl-Schmid J, Natale B, Drzezga A, Förster S, Förstl H, Schwaiger M, Yakushev I, Wester HJ, Kurz A, Yousefi BH. Mol Psychiatry. 2020 Oct;25(10):2643. doi: 10.1038/s41380-018-0302-3. PMID: 30464328 Free PMC article.

Integrity of Neurocognitive Networks in Dementing Disorders as Measured with Simultaneous PET/Functional MRI. (link is external)

Ripp I, Stadhouders T, Savio A, Goldhardt O, Cabello J, Calhoun V, Riedl V, Hedderich D, Diehl-Schmid J, Grimmer T, Yakushev I. J Nucl Med. 2020 Sep;61(9):1341-1347. doi: 10.2967/jnumed.119.234930. Epub 2020 May 1. PMID: 32358091 Free article.

Age and the association between apolipoprotein E genotype and Alzheimer disease: A cerebrospinal fluid biomarker-based case-control study. (link is external)

Saddiki H, Fayosse A, Cognat E, Sabia S, Engelborghs S, Wallon D, Alexopoulos P, Blennow K, Zetterberg H, Parnetti L, Zerr I, Hermann P, Gabelle A, Boada M, Orellana A, de Rojas I, Lilamand M, Bjerke M, Van Broeckhoven C, Farotti L, Salvadori N, Diehl-Schmid J, Grimmer T, Hourregue C, Dugravot A, Nicolas G, Laplanche JL, Lehmann S, Bouaziz-Amar E; Alzheimer’s Disease Neuroimaging Initiative, Hugon J, Tzourio C, Singh-Manoux A, Paquet C, Dumurgier J. PLoS Med. 2020 Aug 20;17(8):e1003289. doi: 10.1371/journal.pmed.1003289. eCollection 2020 Aug. PMID: 32817639 Free PMC article.

Regional Cerebral Associations Between Psychometric Tests and Imaging Biomarkers in Alzheimer's Disease. (link is external)

Hedderich DM, Drost R, Goldhardt O, Ortner M, Müller-Sarnowski F, Diehl-Schmid J, Zimmer C, Förstl H, Yakushev I, Jahn T, Grimmer T. Front Psychiatry. 2020 Aug 13;11:793. doi: 10.3389/fpsyt.2020.00793. eCollection 2020. PMID: 32903760 Free PMC article.

Therapeutic Drug Monitoring of Rivastigmine and Donepezil Under Consideration of CYP2D6 Genotype-Dependent Metabolism of Donepezil. (link is external)

Ortner M, Stange M, Schneider H, Schröder C, Buerger K, Müller C, Müller-Sarnowski F, Diehl-Schmid J, Förstl H, Grimmer T, Steimer W. Drug Des Devel Ther. 2020 Aug 11;14:3251-3262. doi: 10.2147/DDDT.S247259. eCollection 2020. PMID: 32848364 Free PMC article.

Variability of clinical syndromes and cerebral glucose metabolism in symptomatic frontotemporal lobar degeneration associated with progranulin mutations. (link is external)

Licata A, Grimmer T, Winkelmann J, Wagner M, Goldhardt O, Riedl L, Roßmeier C, Yakushev I, Diehl-Schmid J. Amyotroph Lateral Scler Frontotemporal Degener. 2020 Aug;21(5-6):389-395. doi: 10.1080/21678421.2020.1779302. Epub 2020 Jun 22. PMID: 32567375

Serum Concentrations of Cholinesterase Inhibitors in Patients With Alzheimer's Dementia Are Frequently Below the Recommended Levels. (link is external)

Ortner M, Stange M, Schneider H, Schroeder C, Buerger K, Müller C, Dorn B, Goldhardt O, Diehl-Schmid J, Förstl H, Steimer W, Grimmer T. Front Pharmacol. 2020 May 21;11:691. doi: 10.3389/fphar.2020.00691. eCollection 2020. PMID: 32508640 Free PMC article.

The overnight reduction of amyloid β 1-42 plasma levels is diminished by the extent of sleep fragmentation, sAPP-β, and APOE ε4 in psychiatrists on call. (link is external)

Grimmer T, Laub T, Hapfelmeier A, Eisele T, Fatke B, Hölzle P, Lüscher S, Parchmann AM, Rentrop M, Schwerthöffer D, Müller-Sarnowski F, Ortner M, Goldhardt O, Kurz A, Förstl H, Alexopoulos P. Alzheimers Dement. 2020 May;16(5):759-769. doi: 10.1002/alz.12072. Epub 2020 Apr 8. PMID: 32270596

Different CSF protein profiles in amyotrophic lateral sclerosis and frontotemporal dementia with C9orf72 hexanucleotide repeat expansion. (link is external)

Barschke P, Oeckl P, Steinacker P, Al Shweiki MR, Weishaupt JH, Landwehrmeyer GB, Anderl-Straub S, Weydt P, Diehl-Schmid J, Danek A, Kornhuber J, Schroeter ML, Prudlo J, Jahn H, Fassbender K, Lauer M, van der Ende EL, van Swieten JC, Volk AE, Ludolph AC, Otto M; German FTLD consortium. J Neurol Neurosurg Psychiatry. 2020 May;91(5):503-511. doi: 10.1136/jnnp-2019-322476. Epub 2020 Mar 4. PMID: 32132225

Normative brain volume reports may improve differential diagnosis of dementing neurodegenerative diseases in clinical practice. (link is external)

Hedderich DM, Dieckmeyer M, Andrisan T, Ortner M, Grundl L, Schön S, Suppa P, Finck T, Kreiser K, Zimmer C, Yakushev I, Grimmer T. Eur Radiol. 2020 May;30(5):2821-2829. doi: 10.1007/s00330-019-06602-0. Epub 2020 Jan 30. PMID: 32002640

Targeted Mass Spectrometry Suggests Beta-Synuclein as Synaptic Blood Marker in Alzheimer's Disease. (link is external)

Oeckl P, Halbgebauer S, Anderl-Straub S, von Arnim CAF, Diehl-Schmid J, Froelich L, Grimmer T, Hausner L, Denk J, Jahn H, Steinacker P, Weishaupt JH, Ludolph AC, Otto M. J Proteome Res. 2020 Mar 6;19(3):1310-1318. doi: 10.1021/acs.jproteome.9b00824. Epub 2020 Feb 26. PMID: 32101007

Correction to: Amyloid PET, FDG-PET or MRI? - the power of different imaging biomarkers to detect progression of early Alzheimer's disease. (link is external)

Ortner M, Drost R, Hedderich D, Goldhardt O, Müller-Sarnowski F, Diehl-Schmid J, Förstl H, Yakushev I, Grimmer T. BMC Neurol. 2020 Mar 5;20(1):80. doi: 10.1186/s12883-020-01649-9. PMID: 32138693 Free PMC article.

2019

Effective connectivity in the default mode network is distinctively disrupted in Alzheimer's disease-A simultaneous resting-state FDG-PET/fMRI study. (link is external)

Scherr M, Utz L, Tahmasian M, Pasquini L, Grothe MJ, Rauschecker JP, Grimmer T, Drzezga A, Sorg C, Riedl V. Hum Brain Mapp. 2021 Sep;42(13):4134-4143. doi: 10.1002/hbm.24517. Epub 2019 Jan 30. PMID: 30697878 Free PMC article.

Amyloid PET, FDG-PET or MRI? - the power of different imaging biomarkers to detect progression of early Alzheimer's disease. (link is external)

Ortner M, Drost R, Hedderich D, Goldhardt O, Müller-Sarnowski F, Diehl-Schmid J, Förstl H, Yakushev I, Grimmer T. BMC Neurol. 2019 Oct 31;19(1):264. doi: 10.1186/s12883-019-1498-9. PMID: 31672138 Free PMC article.

Prognostic value of Alzheimer's biomarkers in mild cognitive impairment: the effect of age at onset. (link is external)

Altomare D, Ferrari C, Caroli A, Galluzzi S, Prestia A, van der Flier WM, Ossenkoppele R, Van Berckel B, Barkhof F, Teunissen CE, Wall A, Carter SF, Schöll M, Choo ILH, Grimmer T, Redolfi A, Nordberg A, Scheltens P, Drzezga A, Frisoni GB; Alzheimer’s Disease Neuroimaging Initiative. J Neurol. 2019 Oct;266(10):2535-2545. doi: 10.1007/s00415-019-09441-7. Epub 2019 Jul 2. PMID: 31267207

Clinical value of cerebrospinal fluid neurofilament light chain in semantic dementia. (link is external)

Meeter LHH, Steketee RME, Salkovic D, Vos ME, Grossman M, McMillan CT, Irwin DJ, Boxer AL, Rojas JC, Olney NT, Karydas A, Miller BL, Pijnenburg YAL, Barkhof F, Sánchez-Valle R, Lladó A, Borrego-Ecija S, Diehl-Schmid J, Grimmer T, Goldhardt O, Santillo AF, Hansson O, Vestberg S, Borroni B, Padovani A, Galimberti D, Scarpini E, Rohrer JD, Woollacott IOC, Synofzik M, Wilke C, de Mendonca A, Vandenberghe R, Benussi L, Ghidoni R, Binetti G, Niessen WJ, Papma JM, Seelaar H, Jiskoot LC, de Jong FJ, Donker Kaat L, Del Campo M, Teunissen CE, Bron EE, Van den Berg E, Van Swieten JC. J Neurol Neurosurg Psychiatry. 2019 Sep;90(9):997-1004. doi: 10.1136/jnnp-2018-319784. Epub 2019 May 23. PMID: 31123142 Free PMC article.

Kallikrein-related peptidases 6 and 10 are elevated in cerebrospinal fluid of patients with Alzheimer's disease and associated with CSF-TAU and FDG-PET. (link is external)

Goldhardt O, Warnhoff I, Yakushev I, Begcevic I, Förstl H, Magdolen V, Soosaipillai A, Diamandis E, Alexopoulos P, Grimmer T. Transl Neurodegener. 2019 Aug 27;8:25. doi: 10.1186/s40035-019-0168-6. eCollection 2019. PMID: 31467673 Free PMC article.

Reduced blood oxygenation level dependent connectivity is related to hypoperfusion in Alzheimer's disease.(link is external)

Göttler J, Preibisch C, Riederer I, Pasquini L, Alexopoulos P, Bohn KP, Yakushev I, Beller E, Kaczmarz S, Zimmer C, Grimmer T, Drzezga A, Sorg C. J Cereb Blood Flow Metab. 2019 Jul;39(7):1314-1325. doi: 10.1177/0271678X18759182. Epub 2018 Feb 12. PMID: 29431005 Free PMC article.

An augmented reality approach for ADL support in Alzheimer's disease: a crossover trial. (link is external)

Rohrbach N, Gulde P, Armstrong AR, Hartig L, Abdelrazeq A, Schröder S, Neuse J, Grimmer T, Diehl-Schmid J, Hermsdörfer J. J Neuroeng Rehabil. 2019 Jun 3;16(1):66. doi: 10.1186/s12984-019-0530-z. PMID: 31159816 Free PMC article. Clinical Trial.

FDG-PET underscores the key role of the thalamus in frontotemporal lobar degeneration caused by C9ORF72 mutations. (link is external)

Diehl-Schmid J, Licata A, Goldhardt O, Förstl H, Yakushew I, Otto M, Anderl-Straub S, Beer A, Ludolph AC, Landwehrmeyer GB, Levin J, Danek A, Fliessbach K, Spottke A,  Fassbender K, Lyros E, Prudlo J, Krause BJ, Volk A, Edbauer D, Schroeter ML, Drzezga A, Kornhuber J, Lauer M; FTLDc Study Group, Grimmer T. Transl Psychiatry. 2019 Jan 31;9(1):54. doi: 10.1038/s41398-019-0381-1. PMID: 30705258 Free PMC article.

Associations of Neprilysin Activity in CSF with Biomarkers for Alzheimer's Disease. (link is external)

Grimmer T, Goldhardt O, Yakushev I, Ortner M, Sorg C, Diehl-Schmid J, Förstl H, Kurz A, Perneczky R, Miners S. Neurodegener Dis. 2019;19(1):43-50. doi: 10.1159/000500811. Epub 2019 Jul 2. PMID: 31266021

Plasma Levels of Soluble AβPPβ as a Biomarker for Alzheimer's Disease with Dementia. (link is external)

Alexopoulos P, Thierjung N, Economou P, Werle L, Buhl F, Kagerbauer S, Papanastasiou AD, Grimmer T, Gourzis P, Berthele A, Hemmer B, Kübler H, Martin J, Politis A,          Perneczky R. J Alzheimers Dis. 2019;69(1):83-90. doi: 10.3233/JAD-181088. PMID: 30909232

Decreased Vascular Pulsatility in Alzheimer's Disease Dementia Measured by Transcranial Color-Coded Duplex Sonography. (link is external)

Ortner M, Hauser C, Schmaderer C, Muggenthaler C, Hapfelmeier A, Sorg C, Diehl-Schmid J, Kurz A, Förstl H, Ikenberg B, Kotliar K, Poppert H, Grimmer T. Neuropsychiatr Dis Treat. 2019 Dec 20;15:3487-3499. doi: 10.2147/NDT.S225754. eCollection 2019. PMID: 31908463 Free PMC article.

Glial Fibrillary Acidic Protein in Serum is Increased in Alzheimer's Disease and Correlates with Cognitive Impairment. (link is external)

Oeckl P, Halbgebauer S, Anderl-Straub S, Steinacker P, Huss AM, Neugebauer H, von Arnim CAF, Diehl-Schmid J, Grimmer T, Kornhuber J, Lewczuk P, Danek A; Consortium for Frontotemporal Lobar Degeneration German, Ludolph AC, Otto M. J Alzheimers Dis. 2019;67(2):481-488. doi: 10.3233/JAD-180325. PMID: 30594925

2018

18F-FIBT may expand PET for β-amyloid imaging in neurodegenerative diseases. (link is external)

Grimmer T, Shi K, Diehl-Schmid J, Natale B, Drzezga A, Förster S, Förstl H, Schwaiger M, Yakushev I, Wester HJ, Kurz A, Yousefi BH. Mol Psychiatry. 2020 Oct;25(10):2608-2619. doi: 10.1038/s41380-018-0203-5. Epub 2018 Aug 17. PMID: 30120417 Free PMC article.

A rare loss-of-function variant of ADAM17 is associated with late-onset familial Alzheimer disease. (link is external)

Hartl D, May P, Gu W, Mayhaus M, Pichler S, Spaniol C, Glaab E, Bobbili DR, Antony P, Koegelsberger S, Kurz A, Grimmer T, Morgan K, Vardarajan BN, Reitz C, Hardy J, Bras J, Guerreiro R, Balling R, Schneider JG, Riemenschneider M; AESG. Mol Psychiatry. 2020 Mar;25(3):629-639. doi: 10.1038/s41380-018-0091-8. Epub 2018 Jul 9. PMID: 29988083 Free PMC article

Functional Decline in Alzheimer's Disease: A Continuum. (link is external)

Grimmer T, Licata A. J Am Geriatr Soc. 2018 Dec;66(12):2239-2240. doi: 10.1111/jgs.15668. Epub 2018 Nov 21. PMID: 30462834 No abstract available.

Rate of β-amyloid accumulation varies with baseline amyloid burden: Implications for anti-amyloid drug trials. (link is external)

Guo T, Dukart J, Brendel M, Rominger A, Grimmer T, Yakushev I; Alzheimer's Disease Neuroimaging Initiative. Alzheimers Dement. 2018 Nov;14(11):1387-1396. doi: 10.1016/j.jalz.2018.05.013. Epub 2018 Jul 4. PMID: 30420035

Prevalence of amyloid-β pathology in distinct variants of primary progressive aphasia. (link is external)

Bergeron D, Gorno-Tempini ML, Rabinovici GD, Santos-Santos MA, Seeley W, Miller BL, Pijnenburg Y, Keulen MA, Groot C, van Berckel BNM, van der Flier WM, Scheltens P, Rohrer JD, Warren JD, Schott JM, Fox NC, Sanchez-Valle R, Grau-Rivera O, Gelpi E, Seelaar H, Papma JM, van Swieten JC, Hodges JR, Leyton CE, Piguet O, Rogalski EJ, Mesulam MM, Koric L, Nora K, Pariente J, Dickerson B, Mackenzie IR, Hsiung GR, Belliard S, Irwin DJ, Wolk DA, Grossman M, Jones M, Harris J, Mann D, Snowden JS, Chrem-Mendez P, Calandri IL, Amengual AA, Miguet-Alfonsi C, Magnin E, Magnani G, Santangelo R, Deramecourt V, Pasquier F, Mattsson N, Nilsson C, Hansson O, Keith J, Masellis M, Black SE, Matías-Guiu JA, Cabrera-Martin MN, Paquet C, Dumurgier J, Teichmann M, Sarazin M, Bottlaender M, Dubois B, Rowe CC, Villemagne VL, Vandenberghe R, Granadillo E, Teng E, Mendez M, Meyer PT, Frings L, Lleó A, Blesa R, Fortea J, Seo SW, Diehl-Schmid J, Grimmer T, Frederiksen KS, Sánchez-Juan P, Chételat G, Jansen W, Bouchard RW, Laforce RJ, Visser PJ, Ossenkoppele R. Ann Neurol. 2018 Nov;84(5):729-740. doi: 10.1002/ana.25333. PMID: 30255971 Free PMC article.

Safety, tolerability and efficacy of the glutaminyl cyclase inhibitor PQ912 in Alzheimer's disease: results of a randomized, double-blind, placebo-controlled phase 2a study. (link is external)

Scheltens P, Hallikainen M, Grimmer T, Duning T, Gouw AA, Teunissen CE, Wink AM, Maruff P, Harrison J, van Baal CM, Bruins S, Lues I, Prins ND. Alzheimers Res Ther. 2018 Oct 12;10(1):107. doi: 10.1186/s13195-018-0431-6. PMID: 30309389 Free PMC article. Clinical Trial

Serum neurofilament light chain in behavioral variant frontotemporal dementia. (link is external)

Steinacker P, Anderl-Straub S, Diehl-Schmid J, Semler E, Uttner I, von Arnim CAF, Barthel H, Danek A, Fassbender K, Fliessbach K, Foerstl H, Grimmer T, Huppertz HJ, Jahn H, Kassubek J, Kornhuber J, Landwehrmeyer B, Lauer M, Maler JM, Mayer B, Oeckl P, Prudlo J, Schneider A, Volk AE, Wiltfang J, Schroeter ML, Ludolph AC, Otto M; FTLDc study group. Neurology. 2018 Oct 9;91(15):e1390-e1401. doi: 10.1212/WNL.0000000000006318. Epub 2018 Sep 12. PMID: 30209235

A multivariate metabolic imaging marker for behavioral variant frontotemporal dementia. (link is external)

Nazem A, Tang CC, Spetsieris P, Dresel C, Gordon ML, Diehl-Schmid J, Grimmer T, Yakushev I, Mattis PJ, Ma Y, Dhawan V, Eidelberg D. Alzheimers Dement (Amst). 2018 Aug 29;10:583-594. doi: 10.1016/j.dadm.2018.07.009. eCollection 2018. PMID: 30417069 Free PMC article.

An Explorative Note on Apraxia Tests. (link is external)

Gulde P, Leippold K, Armstrong A, Kohl S, Grimmer T, Diehl-Schmid J, Hermsdörfer J. Front Neurol. 2018 Aug 8;9:660. doi: 10.3389/fneur.2018.00660. eCollection 2018. PMID: 30135679 Free PMC article.

Plasma levels of soluble amyloid precursor protein β in symptomatic Alzheimer's disease. (link is external)

Alexopoulos P, Gleixner LS, Werle L, Buhl F, Thierjung N, Giourou E, Kagerbauer SM, Gourzis P, Kübler H, Grimmer T, Yakushev I, Martin J, Kurz A, Perneczky R. Eur Arch Psychiatry Clin Neurosci. 2018 Aug;268(5):519-524. doi: 10.1007/s00406-017-0815-9. Epub 2017 Jun 10. PMID: 28602012

Prevalence of the apolipoprotein E ε4 allele in amyloid β positive subjects across the spectrum of Alzheimer's disease. (link is external)

Mattsson N, Groot C, Jansen WJ, Landau SM, Villemagne VL, Engelborghs S, Mintun MM, Lleo A, Molinuevo JL, Jagust WJ, Frisoni GB, Ivanoiu A, Chételat G, Resende de Oliveira C, Rodrigue KM, Kornhuber J, Wallin A, Klimkowicz-Mrowiec A, Kandimalla R, Popp J, Aalten PP, Aarsland D, Alcolea D, Almdahl IS, Baldeiras I, van Buchem MA, Cavedo E, Chen K, Cohen AD, Förster S, Fortea J, Frederiksen KS, Freund-Levi Y, Gill KD, Gkatzima O, Grimmer T, Hampel H, Herukka SK, Johannsen P, van Laere K, de Leon MJ, Maier W, Marcusson J, Meulenbroek O, Møllergård HM, Morris JC, Mroczko B, Nordlund A, Prabhakar S, Peters O, Rami L, Rodríguez-Rodríguez E, Roe CM, Rüther E, Santana I, Schröder J, Seo SW, Soininen H, Spiru L, Stomrud E, Struyfs H, Teunissen CE, Verhey FRJ, Vos SJB, van Waalwijk van Doorn LJC, Waldemar G, Wallin ÅK, Wiltfang J, Vandenberghe R, Brooks DJ, Fladby T, Rowe CC, Drzezga A, Verbeek MM, Sarazin M, Wolk DA, Fleisher AS, Klunk WE, Na DL, Sánchez-Juan P, Lee DY, Nordberg A, Tsolaki M, Camus V, Rinne JO, Fagan AM, Zetterberg H, Blennow K, Rabinovici GD, Hansson O, van Berckel BNM, van der Flier WM, Scheltens P, Visser PJ, Ossenkoppele R. Alzheimers Dement. 2018 Jul;14(7):913-924. doi: 10.1016/j.jalz.2018.02.009. Epub 2018 Mar 28. PMID: 29601787

Brain-related proteins as potential CSF biomarkers of Alzheimer's disease: A targeted mass spectrometry approach. (link is external)

Begcevic I, Brinc D, Brown M, Martinez-Morillo E, Goldhardt O, Grimmer T, Magdolen V, Batruch I, Diamandis EP. J Proteomics. 2018 Jun 30;182:12-20. doi: 10.1016/j.jprot.2018.04.027. Epub 2018 Apr 22. PMID: 29684683

Sex Differences in Neuropsychological Test Performance in Alzheimer's Disease and the Influence of the ApoE Genotype. (link is external)

Tensil M, Hessler JB, Gutsmiedl M, Riedl L, Grimmer T, Diehl-Schmid J. Alzheimer Dis Assoc Disord. 2018 Apr-Jun;32(2):145-149. doi: 10.1097/WAD.0000000000000229. PMID: 29189302

Step by Step: Kinematics of the Reciprocal Trail Making Task Predict Slowness of Activities of Daily Living Performance in Alzheimer's Disease. (link is external)

Gulde P, Leippold K, Kohl S, Grimmer T, Diehl-Schmid J, Armstrong A, Hermsdörfer J. Front Neurol. 2018 Mar 14;9:140. doi: 10.3389/fneur.2018.00140. eCollection 2018.  PMID: 29593639 Free PMC article.

Fluid biomarker agreement and interrelation in dementia due to Alzheimer's disease. (link is external)

Alexopoulos P, Roesler J, Werle L, Thierjung N, Lentzari I, Ortner M, Grimmer T, Laskaris N, Politis A, Gourzis P, Kurz A, Perneczky R; Alzheimer’s Disease Neuroimaging        Initiative. J Neural Transm (Vienna). 2018 Feb;125(2):193-201. doi: 10.1007/s00702-017-1810-z. Epub 2017 Nov 15. PMID: 29143217

Cognitive Impairment is Associated with Mortality in Hemodialysis Patients. (link is external)

Angermann S, Schier J, Baumann M, Steubl D, Hauser C, Lorenz G, Günthner R, Braunisch MC, Kemmner S, Satanovskij R, Haller B, Heemann U, Lehnert T, Bieber R,      Pachmann M, Braun J, Scherf J, Schätzle G, Fischereder M, Grimmer T, Schmaderer C. J Alzheimers Dis. 2018;66(4):1529-1537. doi: 10.3233/JAD-180767. PMID: 30412499

Increasing Diagnostic Accuracy of Mild Cognitive Impairment due to Alzheimer's Disease by User-Independent, Web-Based Whole-Brain Volumetry. (link is external)

Hedderich DM, Spiro JE, Goldhardt O, Kaesmacher J, Wiestler B, Yakushev I, Zimmer C, Boeckh-Behrens T, Grimmer T. J Alzheimers Dis. 2018;65(4):1459-1467. doi: 10.3233/JAD-180532. PMID: 30175976

Cerebrospinal Fluid BACE1 Activity and sAβPPβ as Biomarker Candidates of Alzheimer's Disease. (link is external)

Alexopoulos P, Thierjung N, Grimmer T, Ortner M, Economou P, Assimakopoulos K, Gourzis P, Politis A, Perneczky R; The Alzheimer’s Disease Neuroimaging Initiative. Dement Geriatr Cogn Disord. 2018;45(3-4):152-161. doi: 10.1159/000488481. Epub 2018 May 22. PMID: 29788013 Free article.

2017

Association of Cerebral Amyloid-β Aggregation With Cognitive Functioning in Persons Without Dementia. (link is external)

Jansen WJ, Ossenkoppele R, Tijms BM, Fagan AM, Hansson O, Klunk WE, van der Flier WM, Villemagne VL, Frisoni GB, Fleisher AS, Lleó A, Mintun MA, Wallin A, Engelborghs S, Na DL, Chételat G, Molinuevo JL, Landau SM, Mattsson N, Kornhuber J, Sabri O, Rowe CC, Parnetti L, Popp J, Fladby T, Jagust WJ, Aalten P, Lee DY, Vandenberghe R, Resende de Oliveira C, Kapaki E, Froelich L, Ivanoiu A, Gabryelewicz T, Verbeek MM, Sanchez-Juan P, Hildebrandt H, Camus V, Zboch M, Brooks DJ, Drzezga A, Rinne JO, Newberg A, de Mendonça A, Sarazin M, Rabinovici GD, Madsen K, Kramberger MG, Nordberg A, Mok V, Mroczko B, Wolk DA, Meyer PT, Tsolaki M, Scheltens P, Verhey FRJ, Visser PJ; Amyloid Biomarker Study Group, Aarsland D, Alcolea D, Alexander M, Almdahl IS, Arnold SE, Baldeiras I, Barthel H, van Berckel BNM, Blennow K, van Buchem MA, Cavedo E, Chen K, Chipi E, Cohen AD, Förster S, Fortea J, Frederiksen KS, Freund-Levi Y, Gkatzima O, Gordon MF, Grimmer T, Hampel H, Hausner L, Hellwig S, Herukka SK, Johannsen P, Klimkowicz-Mrowiec A, Köhler S, Koglin N, van Laere K, de Leon M, Lisetti V, Maier W, Marcusson J, Meulenbroek O, Møllergård HM, Morris JC, Nordlund A, Novak GP, Paraskevas GP, Perera G, Peters O, Ramakers IHGB, Rami L, Rodríguez-Rodríguez E, Roe CM, Rot U, Rüther E, Santana I, Schröder J, Seo SW, Soininen H, Spiru L, Stomrud E, Struyfs H, Teunissen CE, Vos SJB, van Waalwijk van Doorn LJC, Waldemar G, Wallin ÅK, Wiltfang J, Zetterberg H. JAMA Psychiatry. 2018 Jan 1;75(1):84-95. doi: 10.1001/jamapsychiatry.2017.3391. PMID: 29188296